A de novo myeloproliferation arising from an abnormal stem cell. it is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by cytokines arising from the abnormal clone.

Primary myelofibrosis (PMF) is a rare bone marrow blood cancer. It is classified by the World Health Organization (WHO) as a type of myeloproliferative neoplasm, a group of cancers in which there is activation and growth of mutated cells in the bone marrow...