A variant of systemic mastocytosis with involvement of the bone marrow (20% or more mast cells) and the peripheral blood (mast cells account for 10% or more of peripheral blood white cells). (who, 2001) check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/c3169" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/conceptreport.jsp?dictionary=nci%20thesaurus&code=c3169" nci thesaurus)

Mast cell leukemia is an extremely aggressive subtype of acute myeloid leukemia that usually occurs de novo but can, rarely, evolve from transformation of chronic myeloid leukemia into the more aggressive acute myeloid leukemia. In a small proportion of cases, acute mast cell leukemia may evolve from a more progressive form of systemic mastocytosis...