A primary or metastatic malignant neoplasm affecting the pleura. a representative example of primary malignant pleural neoplasm is the malignant pleural mesothelioma. a representative example of metastatic malignant neoplasm to the pleura is when a metastatic carcinoma has spread to the pleura from another anatomic site. check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/c3547" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/conceptreport.jsp?dictionary=nci%20thesaurus&code=c3547" nci thesaurus)