A primary or metastatic malignant neoplasm affecting the mediastinum. representative examples of primary malignant mediastinal neoplasms include malignant germ cell tumors, malignant mesenchymal tumors, lymphomas, and malignant peripheral nerve sheath tumors. a representative example of metastatic malignant neoplasm to the mediastinum is the metastatic carcinoma to the mediastinum from another anatomic site. check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/c3549" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/conceptreport.jsp?dictionary=nci%20thesaurus&code=c3549" nci thesaurus)