An inflammatory lesion comprising large numbers of multinucleated cells that occurs in two forms: one, a central giant cell granuloma that occurs in the jaw, and that is characterised by large lesions that can both expand the cortical plate and resorb roots and move teeth; and, two, a peripheral giant cell granuloma that is found in soft tissue, usually the gingiva, is small, usually less than two centimeters, and often ulcerated. treatment for both forms is most often surgical removal.