Increased level of cryoglobulins in the blood. cryoglobulins are abnormal immunoglobulins, especially igg or igm, that precipitate spontaneously when serum is cooled below 37 degrees celsius. [https://orcid.org/0000-0002-0736-9199]

Cryoglobulinemia is a medical condition in which the blood contains large amounts of cryoglobulins (atypical proteins in the blood) that become insoluble at low temperatures. Cryoglobulinemia is also one of three types in its own family...