Infection with a fungus of the genus coccidioides, species c. immitis; primary form is an acute, benign, self limited respiratory infection due to inhalation of spores and varying in severity; secondary form is a virulent, severe, chronic, progressive granulomatous disease with systemic involvement.

Coccidioidomycosis (, kok-SID-ee-oy-doh-my-KOH-sis) is a mammalian fungal disease caused by Coccidioides immitis or Coccidioides posadasii. It is commonly known as cocci, Valley fever, as well as California fever, desert rheumatism, or San Joaquin Valley fever...