cherubism
Medical Definition
A rare autosomal dominant inherited disorder usually caused by mutations in the sh3bp2 gene. it is characterized by a prominent lower part of the face due to bilateral replacement of the mandibular or maxillary bones by lesions. the lesions contain osteoclast-like cells admixed with spindle-shaped mononuclear stromal cells. with time, the lesions become more fibrotic and less osteoclast-rich.
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