A genetic syndrome caused by mutations in the pten gene. it is characterized by macrocephaly and the presence of hamartomas. check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/c3939" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/conceptreport.jsp?dictionary=nci%20thesaurus&code=c3939" nci thesaurus)