Rare leukoencephalopathy with infantile-onset accumulation of rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. rosenthal fibers are glial fibrillary acidic protein aggregates found in astrocytes. juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. de novo mutations in the gfap gene are associated with the disease with propensity for paternal inheritance.

Alexander disease is a very rare autosomal dominant leukodystrophy, which are neurological conditions caused by anomalies in the myelin which protects nerve fibers in the brain. The most common type is the infantile form that usually begins during the first two years of life...